160606 | Frontiers in Neurology | June 2016 | Volume 7 | Article 74 | Gregory D. Myer, Weihong Yuan, Kim D. Barber Foss, David Smith, Mekibib Altaye, Amit Reches, James Leach, Adam W. Kiefer, Jane C. Khoury, Michal Weiss, Staci Thomas, Chris Dicesare, Janet Adams, Paul J. Gubanich, Amir Geva, Joseph F. Clark, William P. Meehan III, Jason P. Mihalik and Darcy Krueger
OBJECTIVES: Utilize a prospective in vivo clinical trial to evaluate the potential for mild neck compression applied during head impact exposure to reduce anatomical and physiological biomarkers of brain injury. Conclusion: Group differences in the longitudinal changes in both neuroanatomical and electrophysiological measures, as well as the correlation between the measures, provide initial evidence indicating that mild jugular vein compression may have reduced alterations in the WM response to head impacts during a competitive hockey season. The data indicate sport-related alterations in WM microstructure were ameliorated by application of jugular compression during head impact exposure. These results may lead to a novel line of research inquiry to evaluate the effects of protecting the brain from sports-related head impacts via optimized intracranial fluid dynamics.