RESULT...

"It was as if the blast never happened!"

BENEFITS of SAGE CPR4Brain

• Stops neuron death in under 10 seconds
• Protects against LONG TERM BRAIN DAMAGE
• POINT-OF-INJURY brain protection "like" CPR
• "Pocket-size" ~3 oz
• No external power sources
• Multiple human "use-cases" on record!
• TBI PROTECTION, where none exited before

How the SAGE Works

• Recycles your own exhaled air
• Maintains CO₂ at optimal levels
• "Channeled" airflow
• Automatically "FAILSAFE"
• Brain Personal Protection Equipment
• TBI Protection where none previously existed

Cases

"Spreading Depolarizations (SDs) and outcome after traumatic brain injury: A prospective obervational study" | Lancet Neurol 2011: 10: 1058-64.

—Jed Hartings, PhD | Director of Neurotrauma Research at University of Cincinnati | Trained at Walter Reed & Considered as world's leading authority on montiroing SDs.

SD "Tsunamis" created: Waves of complete breakdown of cellular homeostasis in brain's gray matter (60% incidence in clinically severe TBI).

7-fold greater risk of poor outcome (severe disability or death)!

So… what factor determines when SDs cause isoelectric flatline?

HYPOCAPNIA!

Data from 800 hours of ICU monitoring of SD and _ETCO₂

Amazing Case Study at University of Cincinnati

• 28 y/o male MVA patient in Neuro-ICO
• Decmpressive Craniectomy/ICP Bolt— SD Probe in place
• Day 6— marked increase in SDs with iso-electric flat-lining
• Clinically labelled "Brain Dead"
• Dr. Hartings received family consent to raise CO₂ to 47mmHg
• Four hours later— COMPLETE CESSATION of all SDs!
• Patient AWOKE the next morning
• Patient ultimately DISCHARGED from hospital… walking!